Biomedical Research related to health and complex illness

501(c)(3) charity; gifts are tax-deductible.
99¢ of each $1 spent went to programs.
$160K paid to officers and key staff.
Mission: Form 990 Part I, line 1 · Status: IRS Pub. 78 · Programs: Part IX · Pay: Part VII

Before you give

FY2023 · Form 990Independent: from IRS data, not the org
Download 990
IRS status
501(c)(3)
not on the IRS revocation list
Looks good: listed by the IRS and not on the revocation list.
IRS BMF · Auto-Revocation List
Tax-deductible gifts
Yes
Donations are tax-deductible
Looks good: the IRS lists gifts to it as deductible.
IRS Pub. 78 · IRS BMF
Latest return
FY2024
latest Form 990
Looks good: the latest return is for FY2024, 2 tax years back; within 2 tax years.
IRS e-file · Filing history
Surplus or deficit
2 of 4
filings with a surplus
Average surplus $768K a year · 8% of revenue · last 4 filings
Worth a look: a surplus in 2 of the last 4 filings.
Pt I · Ln 19 · 4 filings
Spent on programs
99%
of spending
Looks good: 99% of spending went to programs; 75% or more.
Pt IX · Ln 25 · col B
Pay to officers and key staff
$160K
to officers and key staff · 0.9% of spending
Looks good: pay to officers and key staff is 1% of spending; 15% or less.
Pt VII · Sec A
9 mo
of spending, in cash
Looks good: 9.3 months of spending in cash; 3 or more.
Pt X · Ln 1–2 · Pt I · Ln 18
Named funders
1
named funder · $25K
Fine: 1 funder names it on their filings; under 3.
Funders’ Sch. I, 990-PF
Liabilities
$2.6M
17% of total assets
Looks good: liabilities are 17% of assets; 50% or less.
Pt X · Ln 26
Independent board members
6
of 6 voting members
Looks good: 6 of 6 voting members are independent, a majority.
Pt VI · Ln 1a–1b
Looks goodFineWorth a lookConcernNo data yetTap a box for the reason.
Revenue
$17.4M
-3% vs prior year
Spent
$18.6M
To programs
99%
Net assets
$12.9M
By yearFY2020–FY2024
Revenue
$17.4M
FY2023▼ -3%
Tap a bar for its year
Revenue by fiscal year
FY2020$24K
FY2021$623K
FY2022$17.9M
FY2023$17.4M
FY2024$4.3M
Expenses
$18.6M
FY2023▲ +334%
Tap a bar for its year
Expenses by fiscal year
FY2020Not on file
FY2021$34K
FY2022$4.3M
FY2023$18.6M
FY2024$14.1M
Net assets
$12.9M
FY2023▼ -9%
Tap a bar for its year
Net assets by fiscal year
FY2020$24K
FY2021$612K
FY2022$14.2M
FY2023$12.9M
FY2024$3.1M

From the FY2023 Form 990 · figures checked against the IRS filing · see the original

990 PDF Claim
You’re viewing the FY2023 filing — not the latest on file. See the latest (FY2024) →

Is it real?

Yes. Never revoked by the IRS. Latest filing on record: FY2024. IRS ruling in Aug 2020.

IRS Pub. 78 · IRS Auto-Revocation List · IRS Business Master File

Where the money goes

99 cents of each dollar spent went to programs.

Program services 99% · $18.5M Management & general 1% · $94K Fundraising 0% · $26K

Form 990 Part IX, line 25, columns B–D. Every line is in By the numbers.

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Who runs it and what they're paid

6 people listed on the 990; $160K paid to officers and key staff.

Part VII, Section A · reportable compensation
President
$160,000Pt VII · Sec A
$0Pt VII · Sec A
$0Pt VII · Sec A
$0Pt VII · Sec A
$0Pt VII · Sec A
$0Pt VII · Sec A

Compensation history total reportable pay by year · 1 named individual · Part VII

NameFY2024FY2023FY2022FY2021
Amy Proal$185,000$160,000$52,691$7,692

Total reportable compensation (Form 990 Part VII column D / Schedule J column E) by filing year, matched by name within this organization. The Schedule J base / bonus / deferred breakdown is not parsed into this dataset.

See Polybio Research Foundation executive salaries →

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Questions the 990 asks

The form asks each of these directly. These are the filed answers.

  • Family or business ties among officersPt VI · Ln 2No
  • Top official's pay set by an independent reviewPt VI · Ln 15aYes

Programs and updates

Funds research into health and complex illnesses.

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Provided by the organization

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1 program · $18.5M · in their own filed words · FY2023
01

We conceptualize collaborative research projects on ME/CFS, longcovid and related infection-associated chronic conditions. Our projects study "root cause" drivers of these conditions, and combine the skills of virologists, neuroscientists, pathologists, microbiome experts and patient advocates to maximize impact.

$18.5Mprogram expense

Funders

Who pays for it.

From grant filings on record. Receipts are incomplete: individual donors are never listed.

Grants

Schedule I · received and paid
Grants received · FY2025
Total grants receivedfrom 1 funder$25K
Grants paid · 28 grants · $29.0M · 2022–2024
Regents of the University of California San FranciscoFY2024$3,203,968
University of Pennsylvania School of MedicineFY2024$2,091,756
NYU Grossman School of MedicineFY2024$999,812
Yale UniversityFY2024$575,000
J Craig Venter Institute INCCA · FY2024$290,025
Umass Chan Medical SchoolFY2024$250,000
Stratevi LLCFY2024$201,000
Individual RecipientFY2024$159,128
Georgetown UniversityDC · FY2024$129,305
Brigham and Womens HospitalFY2024$93,128
Unitemized GrantFY2024$60,000
Stanford UniversityFY2024$57,330
University of Texas SouthwesternFY2024$11,124
University of California San FranciscoFY2023$5,078,544
Individual RecipientFY2023$3,342,539
J Craig Venter Institute INCCA · FY2023$2,091,632
See all 28 grants →

By the numbers

The FY2023 990, line by line.

1The main four
Money inPt VIII
$17.4M
Ln 12
Gifts and grantsLn 1h$17.4M
Money outPt IX
$18.6M
Ln 25
Programscol B$18.5M
Managementcol C$94K
Fundraisingcol D$26K
Owns and owesPt X
$12.9M
net assets · Ln 32
Cash and savingsLn 1–2$14.4M
Total assetsLn 16$15.5M
LiabilitiesLn 26$2.6M
PeoplePt VI, VII
6
listed · VII A
PaidVII A1
Voting boardVI 1a6
IndependentVI 1b6
2In more detail
Revenue in detailPt VIII
Gifts and grantsLn 1h$17.4M
Total revenueLn 12$17.4M
Assets in detailPt X, end of year
CashLn 1$14.4M
Cash and savings togetherLn 1–2$14.4M
Total assetsLn 16$15.5M
LiabilitiesLn 26$2.6M
Net assetsLn 32$12.9M
OperationsPt I, VI
EmployeesI 51
VolunteersI 60
Fiscal year endsHeaderDecember
Conflict-of-interest policyVI 12aYes
Whistleblower policyVI 13Yes
Records policyVI 14Yes
3Year over year
Balance sheet, start vs end of yearPt X · col A, B
LineStart FY23End FY23
Cash and savingsLn 1–2$13.9M$14.4M
Total assetsLn 16$14.2M$15.5M
LiabilitiesLn 26$1K$2.6M
Net assetsLn 32$14.2M$12.9M
4Every line
Statement of functional expensesPt IX · every line
LineTotalProgramsManagementFundraising
Grants to domestic organizationsLn 1$16.1M$16.1M
Grants and assistance to foreign recipientsLn 3$2.1M$2.1M
Pay of current officers, directors and key staffLn 5$132K$93K$26K$13K
Payroll taxesLn 10$10K$7K$2K$1K
Legal feesLn 11b$90K$18K$63K$9K
Advertising and promotionLn 12$194$58$68$68
Office expensesLn 13$7K$3K$2K$2K
TravelLn 17$180$162$9$9
InsuranceLn 23$81$49$28$4
Other expenses (24a–d)Ln 24$145K$144K$320$320
Total functional expensesLn 25$18.6M$18.5M$94K$26K

Filing history

YearMoney inMoney outIn minus outNet assetsDownload
FY2024 Latest $4.3M$14.1M−$9.8M$3.1M 990 PDF
FY2023 Viewing $17.4M$18.6M−$1.3M$12.9M 990 PDF
FY2022 $17.9M$4.3M$13.6M$14.2M 990 PDF
FY2021 $623K$34K$588K$612K 990 PDF
FY2020 $24K$24K 990 PDF

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Schedules filed Part IV

III · Programs R · Related orgs G · Fundraising L · Interested persons I · Grants A · Public support F · Foreign J · Pay O · Explanations
See the full FY2023 990 (6 parts)
Part I · Summary $17,350,488 revenue, 12 lines filed
I-8 Contributions and grantsPrior year $17,879,554$17,350,488
I-9 Program service revenuePrior year $0$0
I-10 Investment incomePrior year $0$0
I-11 Other revenuePrior year $0$0
I-12 Total revenuePrior year $17,879,554$17,350,488
I-13 Grants and similar amounts paidPrior year $4,182,914$18,250,077
I-14 Benefits paid to membersPrior year $0$0
I-15 Salaries and benefitsPrior year $59,985$142,327
I-16a Professional fundraising feesPrior year $0$0
I-17 Other expensesPrior year $51,371$242,216
I-18 Total expensesPrior year $4,294,270$18,634,620
I-19 Revenue less expensesPrior year $13,585,284−$1,284,132
Part VI · Governance 6 of 6 board members independent, no flags
VI-1a Voting members of the governing body6
VI-1b Independent voting members6
VI-2 Family or business relationship among officers or directorsNo
VI-12a Written conflict of interest policyYes
VI-13 Written whistleblower policyYes
VI-14 Document retention and destruction policyYes
VI-15a Process for setting top official's payYes
Part VIII · Statement of revenue $17,350,488 across 3 lines filed
VIII-1f All other contributions, gifts and grants$17,350,488
VIII-1h Total contributions, gifts and grants$17,350,488
VIII-12 Total revenueRelated to mission $0 · Unrelated business $0 · Excluded from tax $0$17,350,488
Part IX · Statement of functional expenses $18,634,620 across 10 lines filed
IX-1 Grants to domestic organizationsPrograms $16,123,382$16,123,382
IX-3 Grants and assistance to foreign recipientsPrograms $2,126,695$2,126,695
IX-5 Pay of current officers, directors and key staffPrograms $92,544 · Management $26,441 · Fundraising $13,221$132,206
IX-10 Payroll taxesPrograms $7,085 · Management $2,024 · Fundraising $1,012$10,121
IX-11b Legal feesPrograms $17,949 · Management $62,821 · Fundraising $8,974$89,744
IX-12 Advertising and promotionPrograms $58 · Management $68 · Fundraising $68$194
IX-13 Office expensesPrograms $2,959 · Management $2,219 · Fundraising $2,219$7,397
IX-17 TravelPrograms $162 · Management $9 · Fundraising $9$180
IX-23 InsurancePrograms $49 · Management $28 · Fundraising $4$81
IX-24 Other expenses (24a–d)Programs $143,980 · Management $320 · Fundraising $320$144,620
IX-25 Total functional expensesPrograms $18,514,863 · Management $93,930 · Fundraising $25,827$18,634,620
Part X · Balance sheet $15,536,208 assets, 10 lines filed
X-1 Cash, non-interest-bearingStart of year $13,888,872$14,418,113
X-4 Accounts receivableStart of year $310,000$1,118,095
X-16 Total assetsStart of year $14,198,872$15,536,208
X-18 Grants payable$2,619,336
X-25 Other liabilitiesStart of year $1,457$3,589
X-26 Total liabilitiesStart of year $1,457$2,622,925
X-27 Net assets without donor restrictionsStart of year $1,542,403−$1,894,901
X-28 Net assets with donor restrictionsStart of year $12,655,012$14,808,184
X-32 Total net assets or fund balancesStart of year $14,197,415$12,913,283
X-33 Total liabilities and net assetsStart of year $14,198,872$15,536,208
Part XI · Reconciliation of net assets $12,913,283 net assets at year end
XI-1 Total revenue$17,350,488
XI-2 Total expenses$18,634,620
XI-3 Revenue less expenses−$1,284,132
XI-4 Net assets at start of year$14,197,415
XI-9 Other changes in net assets$0
XI-10 Net assets at end of year$12,913,283

Form 990 e-file (XML) FY2023 from the IRS · Classification, formation year and address from the IRS Business Master File

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