Provide medical-grade porcine islets to replace those lost in type 1 diabetes.

501(c)(3) charity; gifts are tax-deductible.
92¢ of each $1 spent went to programs.
$426K paid to officers and key staff.
Mission: Form 990 Part I, line 1 · Status: IRS Pub. 78 · Programs: Part IX · Pay: Part VII

Before you give

FY2024 · Form 990Independent: from IRS data, not the org
Download 990
IRS status
501(c)(3)
not on the IRS revocation list
Looks good: listed by the IRS and not on the revocation list.
IRS BMF · Auto-Revocation List
Tax-deductible gifts
Yes
Donations are tax-deductible
Looks good: the IRS lists gifts to it as deductible.
IRS Pub. 78 · IRS BMF
Latest return
FY2025
latest Form 990
Looks good: the latest return is for FY2025, 1 tax year back; within 2 tax years.
IRS e-file · Filing history
Surplus or deficit
6 of 6
filings with a surplus
Average surplus $206K a year · 6% of revenue · last 6 filings
Looks good: a surplus in 6 of the last 6 filings.
Pt I · Ln 19 · 6 filings
Spent on programs
92%
of spending
Looks good: 92% of spending went to programs; 75% or more.
Pt IX · Ln 25 · col B
Pay to officers and key staff
$426K
to officers and key staff · 12% of spending
Looks good: pay to officers and key staff is 12% of spending; 15% or less.
Pt VII · Sec A
3 mo
of spending, in cash
Plus $2.2M in investments, Pt X · Ln 11–13
Fine: 2.8 months of spending in cash; 1 to 3.
Pt X · Ln 1–2 · Pt I · Ln 18
Named funders
1
named funder · $22
Fine: 1 funder names it on their filings; under 3.
Funders’ Sch. I, 990-PF
Liabilities
$425K
5% of total assets
Looks good: liabilities are 5% of assets; 50% or less.
Pt X · Ln 26
Independent board members
7
of 7 voting members
Looks good: 7 of 7 voting members are independent, a majority.
Pt VI · Ln 1a–1b
Looks goodFineWorth a lookConcernNo data yetTap a box for the reason.
Revenue
$3.7M
-1% vs prior year
Spent
$3.6M
To programs
92%
Net assets
$7.9M
By yearFY2020–FY2025
Revenue
$3.7M
FY2024▼ -1%
Tap a bar for its year
Revenue by fiscal year
FY2020$2.8M
FY2021$3.5M
FY2022$3.1M
FY2023$3.7M
FY2024$3.7M
FY2025$4.0M
Expenses
$3.6M
FY2024▲ +11%
Tap a bar for its year
Expenses by fiscal year
FY2020$2.7M
FY2021$3.1M
FY2022$3.1M
FY2023$3.2M
FY2024$3.6M
FY2025$3.9M
Net assets
$7.9M
FY2024▲ +0.5%
Tap a bar for its year
Net assets by fiscal year
FY2020$6.9M
FY2021$7.3M
FY2022$7.4M
FY2023$7.8M
FY2024$7.9M
FY2025$8.0M

From the FY2024 Form 990 · figures checked against the IRS filing · see the original

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You’re viewing the FY2024 filing — not the latest on file. See the latest (FY2025) →

Is it real?

Yes. Never revoked by the IRS. Latest filing on record: FY2025. IRS ruling in Aug 2005.

IRS Pub. 78 · IRS Auto-Revocation List · IRS Business Master File

Where the money goes

92 cents of each dollar spent went to programs.

Program services 92% · $3.3M Management & general 8% · $278K Fundraising 1% · $24K

Form 990 Part IX, line 25, columns B–D. Every line is in By the numbers.

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Who runs it and what they're paid

10 people listed on the 990; $426K paid to officers and key staff.

Part VII, Section A · reportable compensation
Executive Director
$206,380Pt VII · Sec A
Director of Quality
$111,982Pt VII · Sec A
Director of Administration
$107,507Pt VII · Sec A
Secretary
$0Pt VII · Sec A
Director
$0Pt VII · Sec A
Chairman
$0Pt VII · Sec A
$0Pt VII · Sec A
$0Pt VII · Sec A

Thomas Spizzo’s $227K as Executive Director is at the 68th percentile of top reported officer pay among 360 $1–10M medical research nonprofits. Peer set: organizations in the same NTEE major field of work and revenue-size band, compared on each org’s own highest-paid officer/key-employee, from Form 990 Part VII / 990-PF Part VIII. Descriptive placement, not a verdict on whether the pay is appropriate.

Compensation history total reportable pay by year · 5 named individuals · Part VII

NameFY2025FY2024FY2023FY2022FY2021FY2020
Thomas Spizzo$227,011$206,380$211,312$196,003$184,929$195,649
Geraldine Hullum$112,921$107,507$106,065———
Megan Larson$105,954$111,982————
Megan Malz——$109,191———
Marie Sheffler—————$104,460

Total reportable compensation (Form 990 Part VII column D / Schedule J column E) by filing year, matched by name within this organization. The Schedule J base / bonus / deferred breakdown is not parsed into this dataset.

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Questions the 990 asks

The form asks each of these directly. These are the filed answers.

  • Family or business ties among officersPt VI · Ln 2Yes
  • Top official's pay set by an independent reviewPt VI · Ln 15aYes

Programs and updates

Supplies medical-grade pig islets to replace those lost in Type 1 diabetes.

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Provided by the organization

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1 program · $3.3M · in their own filed words · FY2024
01

Bred and raised designated pathogen-free (DPF) medical-grade pigs for use in biomedical research to treat and potentially cure type 1 diabetes. Procured pancreata, isolated islets, and produced microencapsulated combination product to finalize investigational new drug (ind) submission and facilitate clinical studies.

$3.3Mprogram expense

Funders

Who pays for it.

From grant filings on record. Receipts are incomplete: individual donors are never listed.

Grants

Schedule I · funders on record
Grants received · FY2023
Total grants receivedfrom 1 funder$22

By the numbers

The FY2024 990, line by line.

1The main four
Money inPt VIII
$3.7M
Ln 12
Fees for servicesLn 2g$3.5M
Investment incomeLn 3$123K
Other incomeLn 4–11$5K
Money outPt IX
$3.6M
Ln 25
Programscol B$3.3M
Managementcol C$278K
Fundraisingcol D$24K
Owns and owesPt X
$7.9M
net assets · Ln 32
Cash and savingsLn 1–2$832K
Total assetsLn 16$8.3M
LiabilitiesLn 26$425K
PeoplePt VI, VII
10
listed · VII A
PaidVII A3
Voting boardVI 1a7
IndependentVI 1b7
2In more detail
Revenue in detailPt VIII
Gifts and grantsLn 1h$3K
Fees for servicesLn 2g$3.5M
Investment incomeLn 3$123K
Other incomeLn 4–11$5K
Total revenueLn 12$3.7M
Assets in detailPt X, end of year
CashLn 1$832K
Cash and savings togetherLn 1–2$832K
InvestmentsLn 11–13$2.2M
Land, buildings, equipmentLn 10c$4.8M
Total assetsLn 16$8.3M
LiabilitiesLn 26$425K
Net assetsLn 32$7.9M
OperationsPt I, VI
EmployeesI 515
VolunteersI 66
Fiscal year endsHeaderDecember
Conflict-of-interest policyVI 12aYes
Whistleblower policyVI 13Yes
Records policyVI 14Yes
3Year over year
Balance sheet, start vs end of yearPt X · col A, B
LineStart FY24End FY24
Cash and savingsLn 1–2$1.1M$832K
InvestmentsLn 11–13$2.0M$2.2M
Land, buildings, equipmentLn 10c$5.0M$4.8M
Total assetsLn 16$8.3M$8.3M
LiabilitiesLn 26$432K$425K
Net assetsLn 32$7.8M$7.9M
4Every line
Statement of functional expensesPt IX · every line
LineTotalProgramsManagementFundraising
Pay of current officers, directors and key staffLn 5$492K$352K$122K$18K
Other salaries and wagesLn 7$812K$812K
Pension plan contributionsLn 8$22K$22K
Other employee benefitsLn 9$111K$111K
Payroll taxesLn 10$87K$78K$8K$1K
Legal feesLn 11b$20K$20K
Accounting feesLn 11c$26K$26K
Investment management feesLn 11f$5K$5K
Other fees for servicesLn 11g$36K$19K$17K
Office expensesLn 13$13K$9K$4K$72
Information technologyLn 14$85K$57K$26K$3K
OccupancyLn 16$24K$7K$16K$1K
TravelLn 17$5K$5K$272
Conferences, conventions and meetingsLn 19$6K$6K
InterestLn 20$280$280
Depreciation, depletion and amortizationLn 22$232K$232K
InsuranceLn 23$78K$70K$9K
Other expenses (24a–d)Ln 24$1.4M$1.4M
All other expensesLn 24e$162K$136K$25K$1K
Total functional expensesLn 25$3.6M$3.3M$278K$24K

Filing history

YearMoney inMoney outIn minus outNet assetsDownload
FY2025 Latest $4.0M$3.9M$111K$8.0M 990 PDF
FY2024 Viewing $3.7M$3.6M$42K$7.9M 990 PDF
FY2023 $3.7M$3.2M$457K$7.8M 990 PDF
FY2022 $3.1M$3.1M$17K$7.4M 990 PDF
FY2021 $3.5M$3.1M$480K$7.3M 990 PDF
FY2020 $2.8M$2.7M$129K$6.9M 990 PDF

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Schedules filed Part IV

III · Programs R · Related orgs G · Fundraising L · Interested persons I · Grants A · Public support J · Pay O · Explanations
See the full FY2024 990 (6 parts)
Part I · Summary $3,653,866 revenue, 12 lines filed
I-8 Contributions and grantsPrior year $6,815$2,905
I-9 Program service revenuePrior year $3,360,225$3,522,919
I-10 Investment incomePrior year $74,645$122,980
I-11 Other revenuePrior year $265,090$5,062
I-12 Total revenuePrior year $3,706,775$3,653,866
I-13 Grants and similar amounts paidPrior year $0$0
I-14 Benefits paid to membersPrior year $0$0
I-15 Salaries and benefitsPrior year $1,330,675$1,523,468
I-16a Professional fundraising feesPrior year $0$0
I-17 Other expensesPrior year $1,918,764$2,088,728
I-18 Total expensesPrior year $3,249,439$3,612,196
I-19 Revenue less expensesPrior year $457,336$41,670
Part VI · Governance 7 of 7 board members independent, 1 to look at
VI-1a Voting members of the governing body7
VI-1b Independent voting members7
VI-2 Family or business relationship among officers or directorsYes
VI-12a Written conflict of interest policyYes
VI-13 Written whistleblower policyYes
VI-14 Document retention and destruction policyYes
VI-15a Process for setting top official's payYes
Part VIII · Statement of revenue $3,653,866 across 6 lines filed
VIII-1f All other contributions, gifts and grants$2,905
VIII-1h Total contributions, gifts and grants$2,905
VIII-2a-f Program service revenue, itemized rows (sum of 2a–2f as filed)Related to mission $3,522,919$3,522,919
VIII-3 Investment incomeExcluded from tax $122,980$122,980
VIII-11a-d Other revenue, itemized rows (sum of 11a–11d as filed)Excluded from tax $5,062$5,062
VIII-12 Total revenueRelated to mission $3,522,919 · Unrelated business $0 · Excluded from tax $128,042$3,653,866
Part IX · Statement of functional expenses $3,612,196 across 19 lines filed
IX-5 Pay of current officers, directors and key staffPrograms $352,387 · Management $121,986 · Fundraising $17,590$491,963
IX-7 Other salaries and wagesPrograms $811,602$811,602
IX-8 Pension plan contributionsPrograms $21,952$21,952
IX-9 Other employee benefitsPrograms $110,739$110,739
IX-10 Payroll taxesPrograms $78,052 · Management $8,068 · Fundraising $1,092$87,212
IX-11b Legal feesManagement $19,956$19,956
IX-11c Accounting feesManagement $26,119$26,119
IX-11f Investment management feesManagement $5,340$5,340
IX-11g Other fees for servicesPrograms $19,323 · Management $16,974$36,297
IX-13 Office expensesPrograms $8,717 · Management $4,359 · Fundraising $72$13,148
IX-14 Information technologyPrograms $57,199 · Management $25,570 · Fundraising $2,577$85,346
IX-16 OccupancyPrograms $7,202 · Management $15,604 · Fundraising $1,200$24,006
IX-17 TravelPrograms $5,089 · Management $272$5,361
IX-19 Conferences, conventions and meetingsPrograms $5,735$5,735
IX-20 InterestManagement $280$280
IX-22 Depreciation, depletion and amortizationPrograms $231,581$231,581
IX-23 InsurancePrograms $69,849 · Management $8,614$78,463
IX-24 Other expenses (24a–d)Programs $1,395,366$1,395,366
IX-24e All other expensesPrograms $135,570 · Management $24,756 · Fundraising $1,404$161,730
IX-25 Total functional expensesPrograms $3,310,363 · Management $277,898 · Fundraising $23,935$3,612,196
Part X · Balance sheet $8,301,984 assets, 14 lines filed
X-1 Cash, non-interest-bearingStart of year $1,074,326$831,868
X-3 Pledges and grants receivableStart of year $15,542$0
X-4 Accounts receivableStart of year $178,527$500,227
X-9 Prepaid expenses and deferred chargesStart of year $41,633$50,063
X-10c Land, buildings and equipment, netStart of year $4,989,125$4,757,544
X-11 Publicly traded securitiesStart of year $1,706,690$1,899,193
X-12 Other securitiesStart of year $263,089$263,089
X-16 Total assetsStart of year $8,268,932$8,301,984
X-17 Accounts payable and accrued expensesStart of year $250,857$243,744
X-19 Deferred revenueStart of year $181,275$181,275
X-26 Total liabilitiesStart of year $432,132$425,019
X-27 Net assets without donor restrictionsStart of year $7,836,800$7,876,965
X-32 Total net assets or fund balancesStart of year $7,836,800$7,876,965
X-33 Total liabilities and net assetsStart of year $8,268,932$8,301,984
Part XI · Reconciliation of net assets $7,876,965 net assets at year end
XI-1 Total revenue$3,653,866
XI-2 Total expenses$3,612,196
XI-3 Revenue less expenses$41,670
XI-4 Net assets at start of year$7,836,800
XI-5 Net unrealized gains (losses) on investments−$1,505
XI-9 Other changes in net assets$0
XI-10 Net assets at end of year$7,876,965

Form 990 e-file (XML) FY2024 from the IRS · Classification, formation year and address from the IRS Business Master File

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