Why Dana-Farber Cancer Institute
FY2024 · Form 990Its mission and biggest programs, as filed- Clinical care - see schedule o$2.58B spent in FY2024
- Research - see schedule o$836M spent in FY2024
- Community benefits - see schedule o$49.3M spent in FY2024
Before you apply
FY2023 · Form 990Independent: from IRS data, not the orgAbout the role
The org's own posting, as writtenThe incoming fellow will join a highly collaborative program with substantial existing datasets, experimental systems, and senior scientific expertise. A planned period of overlap with experienced members of the laboratory will enable deep transfer of computational frameworks, biological knowledge, and experimental context, while providing substantial freedom to establish new questions and approaches. Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS, and related diseases.
We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.
OVERVIEW
The Sethi Laboratory at Dana-Farber Cancer Institute and Harvard Medical School is recruiting an exceptional postdoctoral fellow in computational cancer biology, single-cell genomics, epigenomics, and spatial biology to address these questions across gastrointestinal cancer evolution. Our laboratory studies cell-state plasticity as a fundamental determinant of cancer initiation, progression, and therapeutic resistance.
We combine human samples and patient-derived models with genetically engineered mouse models, organoids, functional genomics, epigenomics, and computational biology to understand: how aberrant developmental and oncofetal cell states are established during premalignant cancer initiation; how metabolic and environmental exposures create durable epigenetic memories that alter future cancer behavior; and how established cancers exploit cellular plasticity to evade targeted therapies.
Our recent work has identified a durable epithelial memory of high-fat-diet exposure, published in Science; characterized therapy-associated polyposis and human premalignant disease models in JCI; demonstrated that differentiation can be therapeutically induced in colorectal cancer in Gastroenterology; and defined mechanisms through which SOX9 and chromatin-remodeling machinery establish tumor-promoting cell states.
RESPONSIBILITIES
The fellow will be expected to independently formulate questions, develop and execute computational analyses, collaborate closely with experimental scientists, interpret complex genomic datasets, present findings internally and externally, contribute to manuscripts and grant applications, and mentor junior trainees.
QUALIFICATIONS
We seek an unusually strong and intellectually curious scientist with a Ph.D., M.D., or M.D./Ph.D. Preferred expertise in quantitative or computational biology. Particularly relevant backgrounds include…
About Dana-Farber Cancer Institute
From its Form 990- Budget $3.47B · Medical Research
- Staff 9,731 · founded 1951
- Pays its leaders $692K–$2.3M (12 reported)
- Open jobs 220 · Jobs at Dana-Farber Cancer Institute · Full 990 report