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Organization	Location	Revenue	Expenses	Assets	Program	Fundr. cost	Employees	Type
Global Down Syndrome Foundation To improve the lives of people with Down Syndrome. 26-4431001 · FY2024	Denver, CO	$4.7M	$4.7M	$8.7M	72%	12%	27	501(c)(3)
The Simple Foundation To support the multi-faceted needs of vulnerable children and families through scholarships, volunteerism… 46-5272775 · FY2024	Omaha, NE	$3.0M	$3.9M	$9.4M	90%	3%	41	501(c)(3)
Down Syndrome of Louisville INC Our mission is to improve the lives of persons with Down Syndrome, and their families, by providing support… 61-1214126 · FY2024	Louisville, KY	$2.6M	$2.9M	$1.1M	68%	1%	49	501(c)(3)
Down Syndrome Association of Greater Cincinnati To empower individuals, educate families, enhance communities and together celebrate the extraordinary lives… 31-1051378 · FY2024	Cincinnati, OH	$1.8M	$1.7M	$4.4M	69%	16%	19	501(c)(3)
Puerto Rico Down Sindrome Foundation INC To provide and promote the conditions that will conduct a person with DOWN syndrome to be included and… 66-0480413 · FY2024	San Juan, PR	$1.6M	$1.4M	$1.4M	49%	0%	20	501(c)(3)
The Down Syndrome Connection of the Bay Area Our mission is to empower, inspire and support people with Down Syndrome, their families and the community… 91-1904304 · FY2024	Danville, CA	$1.2M	$1.2M	$3.5M	80%	6%	39	501(c)(3)
Light Accommodation Foundation To offer a stable, safe and secure living environment for at-risk youth that provides training and… 47-2816406 · FY2024	Houston, TX	$1.2M	$1.2M	$0	48%	0%	5	501(c)(3)
Foundation for Education for Generations To act and operate as a charitable organization to support and provide education for underprivileged families… 80-0718658 · FY2024	Bountiful, UT	$992.1K	$665.6K	$1.6M	99%	1%	—	501(c)(3)
Club 21 Learning and Resource Center INC Club 21 provides learning resources and support to individuals and families with Down Syndrome. 26-2887301 · FY2024	Pasadena, CA	$856.2K	$903.0K	$552.3K	76%	7%	10	501(c)(3)
People with Disabilities Foundation Provide education and advocacy for PEOPLE with psychiatric and/or developmental DISABILITIES with or without… 52-2228353 · FY2023	San Francisco, CA	$764.0K	$474.3K	$2.0M	95%	0%	6	501(c)(3)
Down Syndrome Association of Delaware DOWN SYNDROME ASSOCIATION of DELAWARE, INC. Is a statewide non-profit support group, organized to be a… 20-1874295 · FY2024	Middletown, DE	$720.3K	$856.1K	$877.4K	69%	14%	1	501(c)(3)
Family-Directed Education Foundation To provide educational services to families. 27-1741280 · FY2023	Willis, TX	$704.1K	$665.6K	$13.2K	93%	0%	25	501(c)(3)
Amina Grace Memorial Fund To create lasting acceptance of people with down syndrome and to provide resources to organizations that… 47-1872016 · FY2024	Park Ridge, IL	$598.0K	$361.3K	$1.7M	87%	3%	1	501(c)(3)
Down Syndrome Foundation of Florida INC Our mission is to empower lives for a brighter future by facilitating projects that enhance the welfare… 27-2436041 · FY2024	Orlando, FL	$557.6K	$624.3K	$822.1K	96%	0%	10	501(c)(3)
Friends of Down Syndrome The FRIENDS of DOWN syndromes mission is to create a lifelong of education and learning opportunities for… 26-3412890 · FY2024	Houston, TX	$500.0K	$402.1K	$1.1M	90%	5%	21	501(c)(3)
Down Syndrome Association of Middle Tennessee The organizations mission is to enhance the quality of life throughout the life span of all individuals with… 62-1664176 · FY2024	Hermitage, TN	$453.6K	$538.6K	$355.5K	87%	0%	6	501(c)(3)
Down Syndrome Association of South Texas Provide emotional and educational support for individuals and families with a member having downs SYNDROME… 03-0507948 · FY2024	San Antonio, TX	$441.7K	$488.8K	$1.5M	59%	0%	7	501(c)(3)
Down Syndrome Association of Houston INC To provide lifelong education support and resources to individuals with Down syndrome their families and the… 23-7203655 · FY2024	Houston, TX	$433.5K	$300.9K	$579.4K	81%	1%	13	501(c)(3)
Genuine Foundation Our mission is to aid youth and young adults with autism or down syndrome through activities including, but… 99-2463550 · FY2024	Houston, TX	$400.1K	$336.9K	$63.2K	86%	0%	—	501(c)(3)
Friends of Club 21 Exists to support the efforts of Club 21 to open doors of opportunity for children with Down Syndrome. 47-2201484 · FY2024	Colorado Springs, CO	$384.4K	$349.6K	$191.6K	100%	0%	—	501(c)(3)
Down Syndrome Association of Pittsburgh Is to enrich the lives of individuals with DOWN SYNDROME, their families and communities in which they live… 25-1621542 · FY2024	Pittsburgh, PA	$369.2K	$298.2K	$585.7K	79%	1%	1	501(c)(3)
Young and Prosperous Foundation To provide resources to youths, promote social justice, equality, personal growth and educational development… 26-4433896 · FY2025	Chula Vista, CA	$335.8K	$331.9K	$97.7K	80%	0%	—	501(c)(3)
National Association for Down Syndrome NATIONAL ASSOCIATION for DOWN syndromes mission is to ensure that all persons with DOWN SYNDROME have the… 36-2592338 · FY2024	Park Ridge, IL	$320.4K	$235.6K	$484.9K	79%	14%	7	501(c)(3)
Down Syndrome Association of Connecticut INC To encourage intentionally inclusive communities while providing resources and support to individuals who… 06-1176478 · FY2024	Pawcatuck, CT	$271.4K	$198.1K	$545.7K	56%	17%	2	501(c)(3)
Down Syndrome Association of Central California To enhance the quality of life for all people whose lives are touched by Down Syndrome. 77-0520742 · FY2024	Fresno, CA	$229.3K	$225.2K	$55.5K	54%	25%	4	501(c)(3)
Down Syndrome Association of Greater Toledo To provide education and support programs to individuals with DOWN SYNDROME, their families and community… 34-1354191 · FY2024	Maumee, OH	$213.9K	$185.6K	$358.2K	75%	21%	1	501(c)(3)
All Ways Up Foundation ALL WAYS UP helps first-generation and low-income youth get to and through college. By providing… 46-2843636 · FY2024	Sherman Oaks, CA	$197.9K	$189.6K	$19.6K	93%	0%	3	501(c)(3)
Louis John Lj Piniella Foundation INC To positively impact the world's perspective of individuals with down syndrome. The foundation's goal is to… 88-4329181 · FY2024	Tampa, FL	$179.2K	$150.8K	$63.0K	96%	0%	—	501(c)(3)
Down Syndrome Association of Los Angeles INC Enhance the quality of life of individuals with DOWN SYNDROME by fostering family engagement, encouraging… 51-0198569 · FY2024	Los Angeles, CA	$157.7K	$130.6K	$64.3K	37%	36%	2	501(c)(3)
Miami Valley Down Syndrome Association To improve the lives of individuals with Down Syndrome by providing information, resources, and support to… 31-1179236 · FY2024	Dayton, OH	$146.3K	—	$225.0K	—	—	3	501(c)(3)
Rio Grande Down Syndrome Network Down Syndrome Advocacy Education and Support and community outreach for individuals with down syndrome and… 26-3639311 · FY2024	Albuquerque, NM	$143.1K	$84.1K	$463.7K	79%	1055%	2	501(c)(3)
Team Up for Down Syndrome TEAM UP for DOWN SYNDROME is an organization dedicated to helping improve the lives of individuals and their… 23-2998494 · FY2024	Overland Park, KS	$131.9K	$97.1K	$122.7K	100%	0%	2	501(c)(3)
Utah Down Syndrome Foundation 87-0420378 · FY2024	Salt Lake Cty, UT	$130.1K	—	$218.9K	—	—	—	501(c)(3)
Down Syndrome Foundation of Orange County Fund DOWN SYNDROME services/promote awareness 33-0948722 · FY2023	Newport Beach, CA	$128.5K	$143.3K	$40.0K	35%	0%	2	501(c)(3)
Down Syndrome Foundation 41-1955948 · FY2024	Eden Prairie, MN	$109.2K	—	$232.7K	—	—	—	501(c)(3)
Down Syndrome Support Team INC 42-1677518 · FY2024	Saline, MI	$106.1K	—	$141.4K	—	—	—	501(c)(3)
Down Syndrome Association for Families 04-3701318 · FY2024	Lincoln, NE	$97.2K	—	$161.4K	—	—	—	501(c)(3)
Down Syndrome Family Support & Advocacy Group 35-1813225 · FY2024	Granger, IN	$73.8K	—	$334.4K	—	—	—	501(c)(3)
Southeastern New Mexico Down Syndrome Foundation 26-2042196 · FY2024	Roswell, NM	$53.1K	—	$31.1K	—	—	—	501(c)(3)

2,046,138

nonprofits

212,946

funders

12,515,252

grants

22,549,931

directors

214,365

service providers

549,896,012

financial lines

Public data from IRS Form 990 e-file & Business Master File. A 990 shows reported financial activity, not measured program outcomes. Assets are from the IRS BMF and may lag the latest filing; fundraising cost is fundraising expenses as a share of total expenses. · philanthropy.org