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Organization	Location	Revenue	Expenses	Assets	Program	Fundr. cost	Employees	Type
International Rett Syndrome Foundation To fund research aimed at potential cures for Rett syndrome and to empower families through education 31-1682518 · FY2024	West Chester, OH	$4.8M	$5.5M	$5.3M	86%	8%	9	501(c)(3)
Brain Research Foundation The FOUNDATION is committed to supporting neuroscience RESEARCH that leads to advances in understanding of… 36-2477928 · FY2023	Chicago, IL	$4.0M	$3.1M	$23.4M	70%	5%	3	501(c)(3)
Cure Sanfilippo Foundation To advocate for and fund research directed towards a cure or treatment options for patients with Sanfilippo… 46-4322131 · FY2024	Columbia, SC	$2.8M	$1.6M	$13.9M	80%	9%	4	501(c)(3)
Foundation for Smfm To advance care in pregnancy through research and education. 41-2103331 · FY2024	Washington, DC	$2.0M	$1.1M	$10.0M	66%	11%	—	501(c)(3)
Cerebral Palsy Alliance Research Foundation Cparf funds US-based RESEARCH to change what's possible for people with CEREBRAL PALSY, implements proven… 47-4851754 · FY2024	New York, NY	$1.9M	$2.4M	$1.4M	66%	28%	8	501(c)(3)
Rare Cancer Research Foundation The RARE CANCER RESEARCH FOUNDATION is dedicated to curing RARE cancers through strategic investments and… 46-3405526 · FY2024	Durham, NC	$1.8M	$2.2M	$1.4M	74%	7%	9	501(c)(3)
Prader-Willi Syndrome Association (usa) To enhance the quality of life and empower those affected by PRADER-WILLI SYNDROME. 41-1306908 · FY2024	Brandon, FL	$1.6M	$1.6M	$3.6M	74%	9%	16	501(c)(3)
Cancer Research Foundation - Funding CANCER RESEARCH to find a cure 81-2771469 · FY2024	Chicago, IL	$1.5M	$1.7M	$1.3M	89%	6%	4	501(c)(3)
Stxbp1 Foundation To create awareness in the disorders associated with STXBP1 mutations. Fund and drive research discovery of a… 82-1439459 · FY2024	Holly Springs, NC	$1.4M	$1.3M	$1.5M	97%	0%	—	501(c)(3)
American Migraine Foundation INC Advancement of research and awareness surrounding MIGRAINE 85-2527027 · FY2025	New York, NY	$1.4M	$929.1K	$1.2M	66%	14%	—	501(c)(3)
Kabuki Syndrome Foundation Drive research efforts that show promise to treat or cure KABUKI SYNDROME. 82-5401904 · FY2024	Northbrook, IL	$1.2M	$928.8K	$2.3M	87%	6%	—	501(c)(3)
Cancer Research Foundation Funding CANCER RESEARCH to find a cure 36-2385213 · FY2024	Chicago, IL	$1.2M	$1.6M	$10.2M	88%	4%	1	501(c)(3)
Adnp Kids Research Foundation Rare disease support, patient advocacy, education, and scientific research and funding treatment studies and… 30-0964243 · FY2023	Brush Prairie, WA	$1.1M	$1.1M	$428.1K	100%	0%	—	501(c)(3)
The American Pediatric Society INC The object of the SOCIETY is to bring together people for the advancement of the study of children and their… 16-6078165 · FY2023	The Woodlands, TX	$1.1M	$984.9K	$3.4M	55%	0%	—	501(c)(3)
Monoamine Oxidase Deficiency Foundation The primary charitable mission of the MONOAMINE OXIDASE DEFICIENCY FOUNDATION (the "corporation") is to… 88-0987512 · FY2024	Galveston, TX	$920.7K	$740.7K	$209.6K	100%	0%	—	501(c)(3)
Asxl Rare Research Endowment Foundation A family-led organization that supports research to increase the understanding of the ASXL gene family and… 82-3890665 · FY2024	Gorham, ME	$887.6K	$474.9K	$1.1M	80%	5%	1	501(c)(3)
International Foundation for Gastrointestinal Disorders INC Our mission is to inform, assist, and support people affected by GASTROINTESTINAL (gi) DISORDERS. 39-1710898 · FY2024	Mt Pleasant, SC	$725.4K	$742.9K	$2.4M	76%	9%	7	501(c)(3)
Foundation for Rare Disease Research INC Discover, pursue and support the development of clinical diagnostics tools that can lead to cures for rare… 92-0534021 · FY2024	Silver Spring, MD	$668.5K	$1.5M	$2.4M	100%	0%	—	501(c)(3)
Digestive Disease Research Foundation Conduct and support medical RESEARCH in the field of gastroenterology. 55-0823815 · FY2024	New York, NY	$454.9K	$99.4K	$926.1K	96%	0%	—	501(c)(3)
Bardet Biedl Syndrome Foundation The organization's mission is to build a community of support for individuals and families, provide… 46-3343666 · FY2022	West Chester, PA	$372.6K	$172.2K	$609.1K	100%	0%	—	501(c)(3)
The American-Portuguese Biomedical Research Fund INC 73-1188521 · FY2024	Norman, OK	$353.3K	$6.8K	$761.2K	0%	0%	—	501(c)(3)
Ear Research Foundation INC Education, RESEARCH & treatment of hearing & balance disorders 59-1862386 · FY2024	Sarasota, FL	$346.1K	$551.6K	$2.2M	33%	2%	5	501(c)(3)
Hope for Pdcd Foundation Support and fund the development of life-saving treatment for patients with pyruvate dehydrogenase complex… 92-0361943 · FY2024	Folsom, CA	$330.4K	$178.4K	$640.3K	99%	0%	—	501(c)(3)
Texas Prader Willi Association To raise awareness of Prader-Willi Syndrome and assist families with children with Prader-Willi Syndrome. 27-0901783 · FY2024	Houston, TX	$277.7K	$141.8K	$863.8K	87%	7%	—	501(c)(3)
Prader-Willi Homes of California The organization was established to educate the public about Prader Willi Syndrome, to provide social… 41-2260733 · FY2024	Novato, CA	$221.4K	$101.9K	$1.6M	79%	5%	—	501(c)(3)
The Foregut Research Foundation To foster RESEARCH that evaluates outcomes of diagnostic and therapeutic interventions of FOREGUT patients. 85-1101477 · FY2024	Castle Rock, CO	$219.9K	$219.0K	$61.6K	96%	0%	1	501(c)(3)
Prader Willi California Foundation Individuals with PRADER-WILLI syndrome pws should have the opportunity to pursue their hopes and dreams to… 95-3480752 · FY2024	San Diego, CA	$217.0K	$210.7K	$915.9K	77%	0%	1	501(c)(3)
Curenfwithjack Fund research for and educate public about Neurofibromatosis 46-5178351 · FY2024	Alpharetta, GA	$179.3K	$308.0K	$869.4K	72%	22%	—	501(c)(3)
Pediatric Retinal Research Foundation The mission of the PEDIATRIC RETINAL RESEARCH FOUNDATION (prrf) is to support the community of families… 20-4229924 · FY2024	Warren, MI	$153.9K	$261.3K	$1.2M	16%	7%	—	501(c)(3)
Prader-Willi Syndrome Association of Colorado 20-1913724 · FY2024	Littleton, CO	$139.3K	—	$375.0K	—	—	—	501(c)(3)
Childrens Rare Disorders Fund 88-3452294 · FY2023	East Hampton, NY	$126.2K	—	$0	—	—	—	501(c)(3)
Childrens Glaucoma Foundation INC Research *& education to treat CHILDRENS GLAUCOMA 04-3455133 · FY2025	Boston, MA	$123.1K	$158.1K	$1.7M	92%	0%	1	501(c)(3)
Aicardi Syndrome Foundation To provide support to children afflicted with AICARDI SYNDROME 36-3781527 · FY2023	St Charles, IL	$113.5K	$273.4K	$387.4K	95%	0%	—	501(c)(3)
Cri Du Chat Research Foundation INC To advocate for and facilitate research for the rare genetic syndrome, Cri du Chat/5p Minus syndrome. To… 47-1749667 · FY2024	Brooklyn, NY	$100.1K	$83.8K	$179.4K	63%	34%	—	501(c)(3)
Post-Finasteride Syndrome Foundation To promote public and professional awareness of the POST-FINASTERIDE SYNDROME. 46-0573960 · FY2024	Somerset, NJ	$91.4K	$76.1K	$32.3K	45%	0%	—	501(c)(3)
Friends of Ipwso Support individuals, families and caregivers with Prader Willi Syndrome internationally 82-2546968 · FY2025	Eden Prairie, MN	$87.2K	$66.1K	$240.0K	100%	0%	—	501(c)(3)
Lupus Research Foundation 81-5446248 · FY2024	Ham Lake, MN	$78.9K	—	$66.9K	—	—	—	501(c)(3)
Association of Birth Defect Children INC BIRTH DEFECT research for CHILDREN. 59-2193816 · FY2024	Orlando, FL	$65.9K	$186.1K	$3.7M	97%	1%	2	501(c)(3)
Childrens Gaucher Research Fund RESEARCH FUND to find cure for GAUCHER disease. 94-3326753 · FY2024	Granite Bay, CA	$61.1K	$17.2K	$454.0K	90%	0%	—	501(c)(3)
Prader-Willi Syndrome Association of Wisconsin INC 39-1732251 · FY2024	Oconomowoc, WI	$49.3K	—	$89.2K	—	—	—	501(c)(3)

2,046,138

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212,946

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Public data from IRS Form 990 e-file & Business Master File. A 990 shows reported financial activity, not measured program outcomes. Assets are from the IRS BMF and may lag the latest filing; fundraising cost is fundraising expenses as a share of total expenses. · philanthropy.org